Leaky gut, also known as increased intestinal permeability, is a condition in which bacteria, metabolic breakdown products and toxins are able to “leak” through the intestinal wall and into your bloodstream. The substances entering the circulation
Symptoms associated with the condition may include bloating, gas, cramps, chronic fatigue, joint pain, headaches, skin rashes and abdominal pain. The intestinal lining is the first line of defense for our immune system. With leaky gut, cells lining your intestines don’t maintain the tight barrier needed to ensure your body is only absorbing properly- digested nutrients; unprocessed molecules are allowed to enter the blood stream. When these “foreigners” enter your blood stream, the immune system jumps into action and increases inflammation around the gut wall where the “problem” is, and may also cause problems throughout the whole body.
The Relation Between Leaky Gut and Food Sensitivities
Over time, as the food particles (antigens) continue to pass through the permeable intestinal wall and build up in the bloodstream, the immune system responds by creating IgG antibodies which can form complexes with the antigens. The IgG-antigen complexes are usually cleared by macrophages, but in the presence of excess antigen, the capacity of the macrophages to remove immune complexes is exceeded. This results in deposition of excess complexes in tissue.[1,2] Deposition of IgG-Ag complexes exacerbates inflammation and tissue damage, creating a cycle which may contribute to specific health issues.
